The above results indicated that the mRNA and protein expression levels of the mitochondrial respiratory chain, energy metabolism-related genes and the Ca2+ channel component protein MICU1 and MCU were reduced in E-Wat by HFD/STZ-induced, indicating that mitochondrial dysfunction and energy metabolism disorder were impaired in the E-Wat of T2DM mice, and THF improved the mitochondrial function of E-Wat in T2DM mice which might be related to AMPK-MICU1 pathway. Here, CA2 is linked to type 2 diabetes mellitus.