PCOS itself does not lead to an increase in OS levels, and the increase in OS levels in PCOS is related to other potential factors, such as hyperandrogenism, low-density lipoprotein, high-density lipoprotein, sex hormone-binding globulin, body mass index, triacylglycerol, and age at menarche. The gene discussed is SHBG; the disease is hyperandrogenism.