The analysis revealed a significant escalation in stroke risk concomitant with elevated CVAI quartiles after accounting for confounding factors such as sex, marital status, LDL-C, smoking habits, CRP, hypertension history, geographical location, alcohol consumption, educational background, and diabetes prevalence (P for trend < 0.001, OR: 2.33, 95% CI: 1.67–3.28). Here, CRP is linked to diabetes mellitus.