The considered covariates for adjustment included demographic and behavioral factors such as sex [32], marital status [33], educational attainment [34, 35], geographic location [36], smoking habits [37], and alcohol consumption [38], along with diseases history like presence of diabetes [39], hypertension [40], LDL-C [41, 42], and CRP levels [43]. The gene discussed is CRP; the disease is Hypertension.