ANCOVA revealed that the difference in zonulin between CTR and LOAD, MIXED dementia or aMCI remained statistically significant even after adjustment for age, sex, education, hemoglobin, FT4, and fasting glucose (ANCOVA p=0.01; CTR vs. LOAD, p=0.01; CTR vs. MIXED, p=0.003; aMCI vs. controls, p=0.04). Here, HP is linked to dementia.