HP and dementia: Compared to CTR (33.5±3.4 pg zonulin/mg total proteins ± SE), the mean value of serum zonulin was 1.4 times higher in aMCI (47.0±4.2 pg zonulin/mg total proteins ± SE; p=0.04) patients; 1.6 times higher in LOAD (55.2±4.4 pg zonulin/mg total proteins ± SE; p=0.001); 2 times more abundant in MIXED dementia (69.6±10.6 pg zonulin/mg total proteins ± SE; p=0.008 (Fig. 2).