Although IL-25 and IL-33 have a collaborative and differential effect on effector T helper cells, infection with high-virulence C. neoformans may alter CD4+ T helper to express both IL-17RB and ST2 for the cooperative effect of IL-25 and IL-33 in mediating amplification of pathogenic Th cell response to support cryptococcal brain dissemination. Here, CD4 is linked to infection.