CD4 and neoplasm: Some T cell subtypes (including exhausted CD8+ T cells, non-classical CD8+CD4+ T cells, and relapsed tumor-enriched CD161+CD8+ T cells), LAMP3+ migration DCs, endothelial cells driving immunosuppressive macrophages, CCL4+ tumor-associated neutrophils and VEGFA+ malignant cells are highlighted and well discussed.16,39–44 However, lack of spatial information, the particular interactions in some concerned regions such as the invasive front have not been decoded yet.