Multiplexed IF staining showed that CXCL6+ tumor cells were located near the SAAs+ hepatocytes in the invasive zone, which highly expressed STAT3 and C-X-C Motif Chemokine Receptor 2 (CXCR2), the receptor of CXCL635 (Fig. 4h, l; Supplementary information Fig. S6d). Here, CXCL6 is linked to neoplasm.