PCSK1N and intrahepatic cholangiocarcinoma: Moreover, we found a strong positive correlation between SAAs expression in the invasive zone and the paratumor tissues by IHC staining of the samples from 93 patients with ICC from validation cohort 3, indicating that the damaged hepatocytes in the paratumor tissues reflected the damage detected in the invasive zone (R = 0.75, P < 0.001; Supplementary information, Fig. S10d).