Based on spatial cell-bin segmentation20 with nucleic acid staining and the identification of cell types and status using margin areas (LC12-M), we further validated the spatial aggregation of SAAs+ hepatocytes, SAAs receptor+ macrophages, and CXCL6+ tumor cells close to the border (Supplementary information, Fig. S6h). This evidence concerns the gene CXCL6 and neoplasm.