The tumor margin area was the most active region, representing a sophisticated and dynamic TMEs4,28,45 characterized by the presence of and interactions among highly invasive tumor cells (CXCL6+ tumor cells), damaged hepatocytes (SAAs+ hepatocytes), and recruited FPR1+ macrophages, all of which contributed to tumor progression (Fig. 7). The gene discussed is PCSK1N; the disease is neoplasm.