Some T cell subtypes (including exhausted CD8+ T cells, non-classical CD8+CD4+ T cells, and relapsed tumor-enriched CD161+CD8+ T cells), LAMP3+ migration DCs, endothelial cells driving immunosuppressive macrophages, CCL4+ tumor-associated neutrophils and VEGFA+ malignant cells are highlighted and well discussed.16,39–44 However, lack of spatial information, the particular interactions in some concerned regions such as the invasive front have not been decoded yet. The gene discussed is KLRB1; the disease is neoplasm.