PCSK1N and neoplasm: In addition, macrophages that expressed genes encoding SAAs receptors were spatially accumulated in close proximity to cells of the Hep1 subtype in the invasive zone, and further quantitative analysis revealed the accumulation of SAAs receptor+ macrophages in the first layer (0–250 μm from the border) on the tumor side, supporting that there is recruitment of macrophages via the secretion of SAAs by damaged hepatocytes in the invasive zone (Fig. 5e, f).