To explore the impacts of PON2 expression in mice on tumor-infiltrating myeloid cells, we examined the phenotypic characteristics of two major types of myeloid cells present within the tumors: myeloid-derived suppressor cells (MDSCs)34 and tumor-associated macrophages35, in subcutaneous LLC-bearing WT and PON2-KO mice (Fig. 8). This evidence concerns the gene PON2 and neoplasm.