KCNA5 and atrial fibrillation: We provide insight into the influence H2S on the modulation of Kv1.5, which is associated with adverse electrical remodelling in AF, the reduced remodeling observed following H2S donor GYY4137 supplementation offer a potential therapeutic value for H2S being a regulator of the atrial excitability especially as the incidence of AF increases with age98 and bioavailability of NO25 and H2S99 decreases.