NPM1 and hepatocellular carcinoma: It is found a differences in the levels of IMP1, Koc, p62, RalA, Survivin, Zeta, NPM1, Cmyc, p53, HCC, and p16 with statistically significant before and after HELC (P < 0.05) (Table 2, Fig. 25), it showed the level of iTAA increase in sera after HELC therapy.