We specifically selected representatives of zeta, IMP1, Koc, Survivin, c-MYC, RalA, and p53 gene as marker for research, each gene may have different function in the tumorgenesis, among them, the p53 cancer suppressor gene was a very hot gene studied in the last century, we aimed to provide evidence to prove that HELC treatment induces tumor responses in cancer patients to produce iTAA. This evidence concerns the gene IGF2BP3 and neoplasm.