A previous publication demonstrated that TAAs plus hapten could stimulate the immune system to control tumor shrinkage and keep survival time longer due to DC, CD4 and CD8 increases in tumor tissue and a higher expression of Collal, CD4, IL12aÂ, TGFb1Â, Elastin, NFKB, Cox2, CD11c, CD8 and TNFaÂ in tumor, which are induced by hapten enhanced local chemotherapy (HELC) kill tumor and produce an neu TAAs4,9,10. Here, CD4 is linked to neoplasm.