Moreover, our transcriptomic and proteomic results concord with earlier reports where SAHA has been reported to increase the expression of p53, Bax and cleaved Parp proteins while decreasing the expression of HDACs1/2/3/4/5/6/7/8 and Bcl-2 proteins which controlled the growth of colon cancer by inducing apoptotic-mediated cell death89,111,112. Here, TP53 is linked to malignant colon neoplasm.