MYC and Burkitt lymphoma: While certainly, the number of c-MYC–WDR5 cobound genes identified previously was small in comparison to the number of total c-MYC-targets identified [9], they contained numerous tumor-critical genes encoding ribosomal protein subunits, nucleolar RNAs, and translation initiation factors, all of which when disconnected from the totality of c-MYC gene expression was enough to result in tumor failure in a Burkitt lymphoma model [9].