WDR5 and glioblastoma: WDR5 is best known for its role in promoting the assembly of MLL/SET methyltransferase complexes through its physical interactions within the WRAD (WDR5–RBBP5–ASH2L–DPY30) complex, which has been shown to be important in multiple cancers such as leukemia [11, 12] and glioblastoma [13].