Chromatin immunoprecipitation followed by next-generation sequencing (ChIP-seq) of N-MYC and WDR5 in two N-MYC amplified neuroblastoma cell lines reveals that colocalization of N-MYC and WDR5 occurs invariably at genomic regions associated with genes involved in protein synthesis and includes the sites in which WDR5 can recruit N-MYC to chromatin. Here, MYCN is linked to neuroblastoma.