Taken together, our results reveal that across multiple N-MYC-amplified neuroblastoma cell lines, N-MYC and WDR5 colocalize invariably at genes linked to protein synthesis, but that context-dependent N-MYC–WDR5 cobound genes may be an important factor to keep in mind when considering how N-MYC and WDR5 ultimately influence N-MYC-amplified neuroblastoma. The gene discussed is WDR5; the disease is neuroblastoma.