We recently confirmed phosphorylation of the PEAK3 TYSNL (pY24) motif in cells and showed this is required for recruitment of Grb2, and possibly CrkII and ASAP114, an Arf GTPase-activating protein that regulates cytoskeletal remodeling and is associated with tumor progression and invasiveness31,33,34. The gene discussed is GRB2; the disease is neoplasm.