By performing a differential analysis between the two tumor cell compartments, we found that numerous genes associated with antigen presentation (e.g., HLA-DRA, CD74) were intensively upregulated in APHC, while a variety of metabolic enzymes (e.g., CYP3A5, ALDOB) were highly expressed in ANHC (Fig. 2b). This evidence concerns the gene CYP3A5 and neoplasm.