ERBB2 and neoplasm: For instance, the case study of ‘Elizabeta’ focuses on a diagnosis of grade 3 invasive ductal carcinoma, ER+ve, PR+ve, HER2-ve, with a large tumour infiltrating the chest wall, bilateral axillary masses and nodes in the supraclavicular fossa, small pleural effusions and bone metastases in the spine and right femur.