For instance, the case study of ‘Elizabeta’ focuses on a diagnosis of grade 3 invasive ductal carcinoma, ER+ve, PR+ve, HER2-ve, with a large tumour infiltrating the chest wall, bilateral axillary masses and nodes in the supraclavicular fossa, small pleural effusions and bone metastases in the spine and right femur. Here, ERBB2 is linked to Pleural effusion.