In addition, the expression of NLRP3 inflammasome, and it is downstream inflammatory cytokines IL-1β, and IL-18 was markedly increased in the left ventricle after myocardial infarction in both an animal model of ischemia induced by ligation of the coronary artery and in patients with coronary artery disease [75,93]. Here, IL1B is linked to myocardial infarction.