ZNF146 was reported to be targeting to distinct sites within LINE-1 sequences at thousands of locations in the genome and to promote tumorigenesis of HCC, gastric cancer, and colorectal cancer (Ma et al., 2020; Bao et al., 2021; Zhu et al., 2021; Creamer et al., 2022). This evidence concerns the gene ZNF146 and hepatocellular carcinoma.