Other studies have shown that CTLA-4 therapy is correlated with shorter time to severe irAEs.43 Pulmonary (mainly pneumonitis) and GI (colitis and hepatitis) irAEs had a shorter median time to hospitalization at 77 and 84 days respectively, while endocrine irAEs had a longer time to hospitalization at 111 days. This evidence concerns the gene CTLA4 and pneumonitis.