This transcription factor family is involved in some biological processes, including apoptosis, differentiation, cell proliferation and a series of fibrotic diseases.[16] And studies have found that ECM deposition is also associated with Activator protein 1[28] and ECM activates β-catenin signal in uterine leiomyoma.[23] Vitamin D also inhibits the growth and proliferation of uterine fibroid cells by inhibiting the expression of catechol-O-methyltransferase. This evidence concerns the gene COMT and Uterine leiomyoma.