VDR and vitamin D deficiency: Studies have shown that dietary factors cause vitamin D deficiency in mice, which induces myometrium inflammation.[25] The mechanism by which vitamin D3 inhibits uterine fibroids is related to its effect on ECM deposition, pro-inflammatory pathways, and Wnt/β-catenin in uterine fibroid.[26] In addition, Enhances DNA damage and inhibits repair of damaged DNA by reducing VDR in human myometrium cell.[27] These studies have shown that vitamin D3 interacts with the β-catenin pathway and affects DNA damage and repair.