In contrast, in the BD dataset, the expression levels of hub genes were generally decreased compared with the normal group, among which the statistically significant hub genes were ACTB, ASPM, AURKA, BRCA1, BUB1, CCNA2, CCNB1, CENPE, MCM4, PCNA, RFC4, and RHOA (Fig. 7B). This evidence concerns the gene BUB1 and Behcet disease.