CXCR4 and multiple sclerosis: Some studies have shown that ACTB knockdown can inhibit the migration and invasion of head and neck squamous carcinoma cells through NF-κB and Wnt/β-catenin pathways.[32] Chen et al[33] found that such as ACTB, CXCR4, RHOA, and ITGAM genes can be used as hub genes in multiple sclerosis, and there is a significant downregulation of ACTB, RHOA, and ITGAM.