TP53 and hereditary disease: It has been found that CCNB1 can act as a hub gene of COVID-19, and CCNB1 is closely related to signaling pathways such as P53, which is essential for DNA repair and apoptosis as a TF, and the interaction between CCNB1 and P53 also plays an important role in the regulation of the immune system.[39,40] Mutations in CENPE, a motor protein that plays an important role in chromosome segregation during mitosis and meiosis, are commonly thought to be closely associated with chromosomal instability and some genetic diseases.