It has been found that CCNB1 can act as a hub gene of COVID-19, and CCNB1 is closely related to signaling pathways such as P53, which is essential for DNA repair and apoptosis as a TF, and the interaction between CCNB1 and P53 also plays an important role in the regulation of the immune system.[39,40] Mutations in CENPE, a motor protein that plays an important role in chromosome segregation during mitosis and meiosis, are commonly thought to be closely associated with chromosomal instability and some genetic diseases. This evidence concerns the gene TF and hereditary disease.