In contrast, in the BD dataset, the expression levels of hub genes were generally decreased compared with the normal group, among which the statistically significant hub genes were ACTB, ASPM, AURKA, BRCA1, BUB1, CCNA2, CCNB1, CENPE, MCM4, PCNA, RFC4, and RHOA (Fig. 7B). Here, RFC4 is linked to Behcet disease.