IL6 and COVID-19: Inflammatory factors such as IL-2R, IL-6, and TNF-α have been reported to be significantly increased in PBMCs in COVID-19 patients with severe disease, while IL-10 exhibits fluctuations with disease progression, and IL-10 usually also inhibits the synthesis of cytokines such as IL-2, IL-6, and IL-8, thereby suppressing the immune response, in counteracting cytokine storm-mediated severe disease plays a key role.[14] One of the main manifestations of BD is an increase in PBMCs in the body.