Zinc finger E-box binding homeobox1 (ZEB1) which can induce epithelial -mesenchymal transition (EMT) process through suppression Epithelial-cadherin (E-cad) expression is a driver of EMT and tumor progression.[15,16] ZEB1 could regulate cell differentiation.[17] Aberrant expression of ZEB1 has been found in many types of cancers, such as NSCLC, colorectal cancer, gastric cancer, EC, and pancreatic cancer.[18,19]. This evidence concerns the gene ZEB1 and colorectal cancer.