Abnormal expression of WNT5a should lose its ability of inhibition of movement and invasion of EC.[14] UBE2C knockdown can inhibit tumor cells proliferation, migration, invasion, and EMT,[12,13] therefore, overexpression of UBE2C should promote tumor cells invasion and EMT.[8] However, the methodology of subjects in our study was relatively simple; further studies with more methodologies (such as in vitro and in vivo models) are needed to verify the present observation. This evidence concerns the gene WNT5A and neoplasm.