Ubiquitin-conjugating enzyme E2C (UBE2C), a ubiquitinating enzyme, could catalyze the degradation of proteins into smaller peptides, amino acids and ubiquitin in the 26S proteasome.[4,5] It should be involved in a series of biological processes, such as cell cycle, apoptosis, and transcriptional process.[6] Overexpression of UBE2C can promote tumorigenesis and be associated with unfavorable overall survival (OS) and progression-free survival of cancer patients.[5,7–9]. This evidence concerns the gene UBE2C and cancer.