Tumor protein P53 (TP53), serine/threonine-protein kinase AKT (AKT1), epidermal growth factor receptor (EGFR), estrogen receptor 1 (ESR1), jun proto-oncogene (JUN), sarcoma gene (SRC), and HSP90AA1 in the PPI network had higher values, suggesting that they may be central targets of the BHDH Decoction in the treatment of MS. This evidence concerns the gene ESR1 and myeloid sarcoma.