Jun N-terminal kinase, a member of the MAPK family, is associated with the inhibition of cell proliferation.[38,39] Increasing evidence suggests that the MAPK/ERK pathway is involved in the pathogenesis of depression and mediates the regulation of the circadian system.[40] This suggests that mental symptoms such as insomnia, anxiety, and depression during menopause may be related to the MAPK/ERK pathway. Here, MAPK8 is linked to major depressive disorder.