Our findings are consistent with multiple studies in showing a significant relationship between NLR and the T stage of the disease or tumor size.[15,16,26,28,44,50,51] NLR was also found associated with age,[19,23,26,33,51,57] lymph node status,[26,28] distant metastasis,[28,33,50] clinical staging,[15,19,26,28,33] histopathological grading,[19,26,50] PR status,[50] Ki67 proliferation index,[16] and HER2/neu status.[49,51]. This evidence concerns the gene MKI67 and neoplasm.