It was shown that histological grade (P = .002), HIF-1α (P < .001), VEGF-A (P = .034), and Ki67 (P = .009) were all risk factors, while tumor size, age, and FIGO stage were not risk factors affecting the efficacy of NACT (all P > .05) (Table 4). This evidence concerns the gene MKI67 and neoplasm.