PAX5 and precursor B-cell acute lymphoblastic leukemia: It is imperative in the early stages of B cell lineage development, where it plays a role in the commitment and maintenance of B-cells in childhood B-ALL.[31] However, PAX5 is frequently affected by various mutations, including deletions, amplifications, rearrangements, and point mutations.[32–36] The expression of PAX5 is mainly associated with B lymphocyte maturation, cell survival, motility, and tumor progression, and it varies as cancer progresses.