These fusion genes encode chimeric proteins, which can impair normal B-cell development and contribute to leukemogenesis.[60] PAX5 translocations have been reported in approximately 2% to 3% of pediatric and adult ALL cases.[61] The prevalence and prognostic impact of PAX5 translocations vary depending on the specific fusion gene and other genetic alterations present. Here, PAX5 is linked to acute lymphoblastic leukemia.