PTPN11 and acute lymphoblastic leukemia: Moreover, several inherited disorders have been linked to ALL, including Down syndrome,[7] Swyer syndrome,[8] and Bainbridge-Ropers syndrome.[9] It has been indicated earlier that there is a correlation between numerous germline alleles, variants passed down from parent to child, and somatic mutations in children with ALL.[10,11] Several alleles have been linked to ALL, including IKZF1,[12] PAX5,[13] and ETV6[14] in the germline, and KRAS, NRAS, PTPN11, JAK2, and FLT3[15,16] in the somatic mutations.