Other rearrangements in PAX5 have also been observed with genes such as BCR,[55] MLL,[56] and FOXP1,[57] which lead to the formation of fusion proteins that affect the function of PAX5 and contribute to the development of leukemia.[58] Detecting rearrangements in PAX5 is crucial for diagnosing and classifying ALL, risk stratification, and treatment selection. This evidence concerns the gene PAX5 and leukemia.