Ferroptosis is a novel form of programmed cell death with a complex cell signaling mechanism characterized by iron-dependent lipid peroxide accumulation and loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4).[15,16] Ferroptosis is mostly associated with neoplastic disease.[17] However, iron filariasis has now been shown to have an important pathogenic role in a variety of systemic diseases, such as chronic liver disease and COVID-19.[18–20]. The gene discussed is GPX4; the disease is COVID-19.