Current studies have confirmed that MMP7 promotes the malignant progression of esophageal cancer, colon cancer, and prostate cancer.[33–35] Wang et al confirmed through research that the knockout of BCAR4 inhibits the generation of MMP7 by increasing the expression of miR-227, thereby delaying the pathological process of glioma.[36] And MMP7 was found to be one of the targets of miR-227 by fluorescein analysis. Here, BCAR4 is linked to esophageal cancer.