High TRIM21 expression is associated with better prognosis in patients with diffuse large B-cell lymphoma (DLBCL).[2] By contrast, high TRIM21 levels were associated with lower OS and poor prognosis in pancreatic cancer patients.[10] The specific physiological role and detailed molecular mechanism by which TRIM21 contributes to tumor cells remain unclear. Here, TRIM21 is linked to familial pancreatic carcinoma.