While a significant association between the high level of TRIM21 and worse OS was found in digestive system cancer (random effects model: combined HR = 1.10; 95% CI: 0.69–1.52; P < .001; Fig. 3); subgroup analysis according to pathological type showed a combined HR of 0.74 (95% CI: 0.63–0.85; P = .013) for adenocarcinoma and pooled HR (HR = 0.74; 95% CI: 0.49–1.00; P < .001) for another group (Supplementary Fig. 1, http://links.lww.com/MD/J126). This evidence concerns the gene TRIM21 and adenocarcinoma.