TRIM21 and neoplasm: Stratified analysis according to different tumor sites revealed a significant association between the high level of TRIM21 and better OS in reproductive system tumors (random effects model: combined HR = 0.74; 95% CI: 0.62–0.86; P = .015) and other systems (random effects model: combined HR = 0.50; 95% CI: 0.27–0.72; P < .001; Fig. 3).