Its pathogenesis involves factors such as renal collecting duct obstruction (infectious factors are common) and abnormal embryonic development.[10] Mutations in the RET proto-oncogene are not only related to MEN2 disease but also to the formation of the kidney during the embryonic period.[11] Studies have shown that the RET signaling pathway plays a crucial role in kidney formation, and mutations in RET can lead to renal dysplasia. The gene discussed is RET; the disease is multiple endocrine neoplasia type 2.