In mediation analyses genetic variants in ABCA1 contributed with 6% (3–14%) of the increased risk of all AMD, 8% (3–30%) of the increased risk of nonneovascular AMD, and 6% (3–17%) of the increased risk of neovascular AMD via higher HDL cholesterol (Supplementary Table 2). The gene discussed is ABCA1; the disease is age-related macular degeneration.