The multivariable adjusted hazard ratios (HRs) for all-cause AMD versus individuals in the first tertile of the ABCA1 allele score were 1.13 (1.00 − 1.28) for those in the second and 1.30 (1.14 − 1.49) for individuals in the third tertile (Fig. 1, panel B top; P for trend < 0.001). This evidence concerns the gene ABCA1 and age-related macular degeneration.