Metformin has both chemo-preventative and chemotherapeutic activity which has been studied in pancreatic cancer and demonstrated via down-regulation of specificity protein transcription factors Sp1, Sp3 and Sp4 in pancreatic cancer cells and tumors, accompanied by down-regulation of several pro-oncogenic Sp Regulated genes [49, 50]. This evidence concerns the gene TFF2 and familial pancreatic carcinoma.