METTL3 and alcohol abuse: However, Mettl3 expression was significantly downregulated in the liver of diabetes (db/db) mice and obese (ob/ob) mice (Figure 1C, 1D) but not in the liver of alcohol abuse and alcoholism (NIAAA) mice and high saturated fat, cholesterol, and fructose (FFC) diets induced mice (Figure 1E, 1F) compared to the control.