Apart from tumor suppressor genes and signaling proteins, many cytokines, for example tumor necrosis factor alpha (TNFα), interferons- beta/gamma (IFNβ/γ), and interleukins (IL-12) helped increasing the survival rates by suppressing the tumorigenicity in glioma disease models and human patients [76–79]. The gene discussed is IFNB1; the disease is central nervous system cancer.