Molecular analysis of primary brain tumors suggests that p53, PTEN, isocitrate dehydrogenase (IDH), telomerase reverse transcriptase (TERT), α-thalassemia/mental retardation syndrome X-linked (ATRX), and epithelial growth factor receptor (EGFR) are most commonly mutated genes in these tumors [28]. Here, PTEN is linked to brain neoplasm.