Spinal CSF pressure monitoring in trauma protocols allows for serial CSF159,160 sample collection, enabling retrospective correlations between structural and inflammatory biomarker combinations, AIS grade conversion, and motor score recovery.79,171 One prognostic model using S100β, glial fibrillary acidic protein (GFAP), and IL-8 levels at 24 h post-injury predicted acute AIS grade with nearly 90% accuracy.159 Another model using IL-6, IL-8, MCP-1, tau, S100β, and GFAP predicted AIS grade conversion with 80% accuracy. This evidence concerns the gene CXCL8 and androgen insensitivity syndrome.