These results further imply that MX1 and RSAD2 may play molecular regulatory role in LN disease progression by co-regulating influenza A and hepatitis C. Notably, the AUC value of MX1 and IFI44 in GSE32591_glomeruli and GSE32591_tubulointerstitium datasets is 1, which is worth further exploring its clinical diagnostic value. This evidence concerns the gene MX1 and hepatitis C virus infection.