Besides, Yelong Chen et al. demonstrated that SPARC protein expression and mRNA replication in esophagus tumor tissues were six times higher than the normal tissue in the surrounding, and this high expression was positively correlated with metastasis of ESCC,25 which gives us a lot of confidence that we can use nab‐paclitaxel as part of a comprehensive therapy model in the cure of locally advanced ESCC. The gene discussed is SPARC; the disease is esophageal squamous cell carcinoma.