In the striatum, higher amounts of Glu and decreased levels of GABA, Cho, and Lac were seen in the striatum in the PD group, but the metabolic pattern was restored in the FGF21 + MPTP group by boosting Cho, GABA, and reducing Glu after FGF21 treatment (Figure 3B; Table S2). The gene discussed is FGF21; the disease is Parkinson disease.