We recently identified an innate-like B-1a cell population in mouse peritoneal cavity that produces IL-27 and the IL-27-producing B-1a regulatory cells (i27-Breg) suppress experimental autoimmune uveitis (EAU) or experimental autoimmune encephalomyelitis (EAE), two CNS mouse autoimmune disease models of human uveitis and multiple sclerosis, respectively (15). The gene discussed is IL27; the disease is multiple sclerosis.