Inflammation, NLRP3 activation, Pro-inflammatory cytokines and proteases upregulating, Apoptosis, Angiogenesis, Antigen processing and presentation, ECM and BM proteolysis, Decorin degradation, Proteoglycan 4 degradation, PAR2 cleavage, FKN cleavage, Tuberculosis, COPD, Cardiovascular diseases, Atherosclerosis, Cystic fibrosis (CF), Sjögren’s syndrome, Idiopathic pulmonary fibrosis, Lupus, Obesity, Pain, Cancer, Arthritis, Neuropathy. Here, PRG4 is linked to Sjogren syndrome.