Inflammation, NLRP3 activation, Pro-inflammatory cytokines and proteases upregulating, Apoptosis, Angiogenesis, Antigen processing and presentation, ECM and BM proteolysis, Decorin degradation, Proteoglycan 4 degradation, PAR2 cleavage, FKN cleavage, Tuberculosis, COPD, Cardiovascular diseases, Atherosclerosis, Cystic fibrosis (CF), Sjögren’s syndrome, Idiopathic pulmonary fibrosis, Lupus, Obesity, Pain, Cancer, Arthritis, Neuropathy. Here, DCN is linked to obesity due to melanocortin 4 receptor deficiency.