Antigenic peptides release, Intracellular degradation of elastin, Corneal neovascularization, MHC class II molecules maturation, Elastin fibrils turnover, Intra- and extra-cellular substrates cleavage, Hypertension, Keratoconus corneas, Myasthenia gravis, Atherosclerosis, Aortic aneurysm, Breast cancer, Squamous cell carcinoma, Colorectal cancer. The gene discussed is ELN; the disease is breast cancer.