NLRP3 activation,Apoptosis, Autophagy, Antigen processing and presentation, Spike protein processing, Rheumatoid arthritis, Atherosclerosis, Liver fibrosis, Type I and II diabetes, Cardiac diseases, Bone diseases, Kidney disorders, Immune disorders, Bone turnover, Muscle degeneration, Cancer metastasis. This evidence concerns the gene NLRP3 and immune system disorder.