Inflammation, NLRP3 activation, Pro-inflammatory cytokines and proteases upregulating, Apoptosis, Angiogenesis, Antigen processing and presentation, ECM and BM proteolysis, Decorin degradation, Proteoglycan 4 degradation, PAR2 cleavage, FKN cleavage, Tuberculosis, COPD, Cardiovascular diseases, Atherosclerosis, Cystic fibrosis (CF), Sjögren’s syndrome, Idiopathic pulmonary fibrosis, Lupus, Obesity, Pain, Cancer, Arthritis, Neuropathy. Here, NLRP3 is linked to arthritic joint disease.