Smaller effects (odds ratios ~1.5 to 2.1) are attributed to common variants identified by COVID-19 GWAS studies, linked to genes involved in IFN signaling: risk SNPs in TYK2 and IFNAR2 genes, protective polymorphisms in the OAS1, OAS2, OAS3 cluster of genes, which are ISGs (71–74). This evidence concerns the gene IFNA1 and COVID-19.