In addition, Abrine synergizes with immune checkpoint inhibitor anti-PD-1 antibody to enhance tumor suppression, increases the infiltration of CD8+ T cells in the tumor cells, decreases the expression of CD47 and PD-L1 in tumor tissues, and down-regulate the Foxp3+ Treg cells to exert anti-tumor immune escape. Here, FOXP3 is linked to neoplasm.