The novel interaction between gC1qR and HYAL2 unveiled another regulatory role of gC1qR: by acting on HA metabolism, gC1qR may control the key functions of HA in tumor progression and its involvement in most of the hallmarks of cancer, such as sustenance of proliferative signaling and tumor-promoting inflammation, evasion of apoptosis, induction of angiogenesis, promotion of invasion and metastases, deregulation of energy metabolism and evasion of the immune response (4). This evidence concerns the gene C1QBP and cancer.