Although IL-15 is a promising therapeutic tool, several human solid tumor-derived cell lines and tissues, such as from the colon, head and neck, kidney, lung, triple-negative breast cancers, and melanoma, including uveal melanomas, express intra-tumoral IL-15 and/or IL-15Rα, have been shown to act as tumor promoters and, in a few instances, as protecting factors (8). Here, IL15 is linked to uveal melanoma.