In addition to being crucial for the angiogenesis regulation, the HIF-1 pathway also promotes the proliferation and survival of cancer cells; NF-kB is a protein complex comprised of p50, p52, p65, RelB, and c-Rel subunits as homo- or hetero-dimers, which can act as transcription factors involved in the developmental processes in tumors, such as immune and inflammatory responses. The gene discussed is NFKB1; the disease is cancer.