TGFB1 and neoplasm: Overall, tumor pathological angiogenesis causes functional immune cell inactivation, and the aggregated immunosuppressive cells, together with the tumor cells and endothelial cells of abnormal tumor vessels, promote angiogenesis and the formation of a local or systemic immunosuppressive environment by producing cytokines and growth factors including Ang2, VEGF, TGF-β, and IL-10.