In the inflammatory tumor environment, a series of inflammatory factors secreted by immune cells, and autocrine by tumor cells like VEGF, transforming growth factor-β (TGF-β), fibroblast growth factor (FGF), PDGF, Tumor Necrosis Factor (TNF), and Interleukin (IL), among others, can stimulate angiogenesis in the tumor region (44, 45). This evidence concerns the gene TNF and neoplasm.