The improvement of tumor hypoxia can usually be determined by detecting the oxygen partial pressure in the tumor area with instrumentsor by detecting the expression of hypoxia-related proteins and pathways (HIF-1α) (80–82); (2) Vascular function restoration: When using anti-vascular drugs to achieve the reversal of tumor vascular abnormalities, firstly, it can effectively improve the density, distribution, diameter, morphology, and other characteristics of blood vessels in the tumor area. This evidence concerns the gene HIF1A and neoplasm.