In summary, EGCG may serve a role in preventing obesity-related precocious puberty through targets such as AKT1, EGFR, ESR1, STAT3, IGF1, and MAPK1 that acted on multiple signaling pathways, including the estrogen, PI3K-Akt, MAPK, and Jak-STAT pathways. This evidence concerns the gene MAPK1 and obesity due to melanocortin 4 receptor deficiency.