However, it has been proposed that non-albuminuric patients with diabetes may progress in any case toward chronic kidney disease; as a matter of fact, in a previous study also pediatric individuals with normal albuminuria but mildly reduced eGFR (60-89 mL/min/1.73 m2) showed a worst cardiometabolic risk profile with higher levels of insulin requirement, TG/HDL-C ratio, neutrophil/lymphocytes ratio, blood pressure, uric acid, and low HDL-C levels (22). Here, INS is linked to chronic kidney disease.