GHRL and Hypoglycemia: The lack of either a more attenuated CRR to recurrent hypoglycemia in ghrelin-KO vs. WT littermates or a less attenuated CRR to recurrent hypoglycemia in GhIRKO vs. floxed-IR littermates suggests that ghrelin is not essential in regulating the CRR induced by recurrent hypoglycemia as it is in the settings of a one-time episode of hypoglycemia or a one-time hyperinsulinemic-hypoglycemic clamp protocol.