In WT littermates, recurrent hypoglycemia resulted in a mean blood glucose (56 ± 5 mg/dL) 30 min following insulin administration that was lower (by ~37.9%) than that exhibited by the “1X Hypo” group (Figure 2A); the rise in plasma glucagon and epinephrine observed in the “1X Hypo” group was attenuated in the “Recurrent Hypo” group (Figures 2B, C); plasma ghrelin was lowered by both the “1X Hypo” and “Recurrent Hypo” protocols to a similar degree (Figure 2E). Here, INS is linked to Hypoglycemia.