INS and Hypoglycemia: In floxed-IR control mice, recurrent hypoglycemia resulted in a mean blood glucose (50 ± 2 mg/dL) 30 min following insulin administration that was lower (by ~35%) than that exhibited by the “1X Hypo” group (Figure 3A); the rise in plasma levels of glucagon observed in the “1X Hypo” group was attenuated in the “Recurrent Hypo” group (Figure 3B); plasma ghrelin was lowered by both the “1X Hypo” and “Recurrent Hypo” protocols to a similar degree (Figure 3E).