In particular, as compared to WT littermates, ghrelin-KO mice experience greater hypoglycemia following a 1X i.p. bolus of Humulin-R insulin (2.5 U/kg; noticeable at 90 min to at least 240 min following the insulin bolus, but not at 30 min or 60 min) (24). The gene discussed is INS; the disease is Hypoglycemia.