Most of the autoantigens related to Type 1 Diabetes (T1D) including pro-insulin (1), GAD65 (2) and GAD67 (3), tyrosine phosphatase like protein IA-2, ICA69, S100β, HSP60, and IGRP (4) also follow a nervous system expression pattern. The gene discussed is S100B; the disease is type 1 diabetes mellitus.