According to multivariate analysis, age [OR: 1.126 (95% CI: 1.071–1.183); P < 0.001], ASA classification [OR: 0.282 (95% CI: 0.09–0.885); P = 0.03], preoperative cirrhosis [OR: 0.393 (95% CI: 0.187–0.828); P = 0.014] and ERAS pathway [OR: 0.47 (95% CI: 0.23–0.961); P = 0.038] remained independently associated with a high cost of complicated liver resection (Figure 3B). Here, ERAS is linked to Cirrhosis.