The univariate Cox regression analysis showed that AQP1 (Allred_score and H_score), age, and TNM-stage were risk factors of 5-year PFS and OS for CRC (p < 0.05), while the expression of AQP 3 and AQP5 were not correlated with 5-year PFS and OS (p > 0.05, Table 2). The gene discussed is AQP5; the disease is colorectal carcinoma.