The lipid kinase, diacylglycerol kinase-α (DGKα) must be expressed in fibroblasts for them to generate pro-invasive microenvironments in response to EVs from primary tumors.5 We deployed DGKα knockout (DGKα−/−) mice to determine whether this kinase is required for a “recipient” brain cell population to generate a pro-migratory microenvironment in response to GBM EVs. The gene discussed is DGKA; the disease is glioblastoma.