In conclusion, this study offers a mechanistic explanation for the particularly poor prognosis of IDH-mutant astrocytoma which express the p53R273H mutant and highlights potential druggable targets both within the tumor (Rab35, PODXL) and astrocytes (DGKα) which influence the ECM microenvironment (Supplementary Figure S5). Here, PODXL is linked to neoplasm.