PODXL and carcinoma: PODXL levels in EVs were increased by deletion of mutant p53R273H (Figure 2D); an observation consistent with previous findings in carcinoma cells, and which moots the probability that EVs from p53-KO E2 cells might have altered ability to foster pro-invasive microenvironments.5 Indeed, EVs from p53-KO E2 cells displayed reduced capacity to influence astrocyte ECM deposition in a way that supported migration of GBM cells (Figure 2E).