DGKA and glioblastoma: GBM cells migrated poorly on brain slices from DGKα−/− mice (as they did on slices from DGK+/+ mice) and this was unaffected by pretreatment with EVs from E2 cells, indicating that expression of DGKα is required for a brain cell population to generate a pro-migratory microenvironment in response to GBM EVs (Figure 1A).