DGKA and astrocytoma (excluding glioblastoma): In conclusion, this study offers a mechanistic explanation for the particularly poor prognosis of IDH-mutant astrocytoma which express the p53R273H mutant and highlights potential druggable targets both within the tumor (Rab35, PODXL) and astrocytes (DGKα) which influence the ECM microenvironment (Supplementary Figure S5).