Fibroblasts respond to PODXL-containing EVs by upregulating DGKα-dependent integrin recycling; DGKα operates by generating phosphatidic acid in the plasma membrane to enable docking and fusion of endocytic recycling vesicles.22 Increased DGKα-dependent integrin recycling then changes alignment of fibrillar ECM deposited by fibroblasts to support tumor cell migration.5 Unlike fibroblasts, glial cells do not deposit fibrillar ECM so it is important to consider how DGKα-mediated vesicle trafficking might influence HA deposition by astrocytes. The gene discussed is PODXL; the disease is neoplasm.